Reactome | NRXNs bind NLGNs

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NRXNs bind NLGNs Show undefined attributes

authored	[InstanceEdit:6794360] Garapati, Phani Vijay, 2015-09-04
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6794360] Garapati, Phani Vijay, 2015-09-04
dbId	6794346
displayName	NRXNs bind NLGNs
edited	[InstanceEdit:6794360] Garapati, Phani Vijay, 2015-09-04
eventOf	[Pathway:R-HSA-6794361] Neurexins and neuroligins - Homo sapiens
followingEvent	[Reaction:R-HSA-6797568] NRXNs bind CASK:Protein 4.1 - Homo sapiens [Reaction:R-HSA-6794345] NLGNs binds PSD-95 subfamily members - Homo sapiens
input	[DefinedSet:R-HSA-6794303] NLGN dimers [plasma membrane] [DefinedSet:R-HSA-6794323] NRXNs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6794181] Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons [LiteratureReference:6794175] Neuroligin 1: a splice site-specific ligand for beta-neurexins [LiteratureReference:6794215] A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins [LiteratureReference:6794171] Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex [LiteratureReference:6794172] Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain [LiteratureReference:6794218] Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components [LiteratureReference:6794221] Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses [LiteratureReference:6794198] Neuroligin 2 is exclusively localized to inhibitory synapses [LiteratureReference:6794195] Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses [LiteratureReference:6794193] Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina [LiteratureReference:6794220] Structures, alternative splicing, and neurexin binding of multiple neuroligins [LiteratureReference:6804825] Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NRXNs bind NLGNs Neurexins bind Neuroligins
orthologousEvent	[Reaction:R-CEL-6794346] NRXNs bind NLGNs - Caenorhabditis elegans [Reaction:R-DME-6794346] NRXNs bind NLGNs - Drosophila melanogaster [Reaction:R-GGA-6794346] NRXNs bind NLGNs - Gallus gallus [Reaction:R-XTR-6794346] NRXNs bind NLGNs - Xenopus tropicalis [Reaction:R-DRE-6794346] NRXNs bind NLGNs - Danio rerio [Reaction:R-SSC-6794346] NRXNs bind NLGNs - Sus scrofa [Reaction:R-BTA-6794346] NRXNs bind NLGNs - Bos taurus [Reaction:R-CFA-6794346] NRXNs bind NLGNs - Canis familiaris [Reaction:R-RNO-6794346] NRXNs bind NLGNs - Rattus norvegicus [Reaction:R-MMU-6794346] NRXNs bind NLGNs - Mus musculus
output	[Complex:R-HSA-6794314] NRXNs:NLGN dimers [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809223] Washbourne, Philip, 2015-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6794346
summation	[Summation:6794045] The mammalian genome contains three NRXN genes (NRXN1, NRXN2...

Referrals

(hasEvent)	[Pathway:R-HSA-6794361] Neurexins and neuroligins
(precedingEvent)	[Reaction:R-HSA-6797568] NRXNs bind CASK:Protein 4.1 [Reaction:R-HSA-6794345] NLGNs binds PSD-95 subfamily members

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