Reactome | NRXNs bind NLGNs

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10973504
displayName	NRXNs bind NLGNs
eventOf	[Pathway:R-CEL-6794361] Neurexins and neuroligins - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-6797568] NRXNs bind CASK:Protein 4.1 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-6794346] NRXNs bind NLGNs - Homo sapiens
input	[DefinedSet:R-CEL-6794303] NLGN dimers [plasma membrane] [EntityWithAccessionedSequence:R-CEL-6788636] nrx-1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NRXNs bind NLGNs Neurexins bind Neuroligins
output	[Complex:R-CEL-6794314] NRXNs:NLGN dimers [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-6794346
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-6794361] Neurexins and neuroligins
(precedingEvent)	[Reaction:R-CEL-6797568] NRXNs bind CASK:Protein 4.1
(inferredTo)	[Reaction:R-HSA-6794346] NRXNs bind NLGNs

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