Reactome | Ubiquitinated TP53 translocates to the cytosol

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Ubiquitinated TP53 translocates to the cytosol Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6793686] Orlic-Milacic, Marija, 2015-09-03
dbId	6793685
displayName	Ubiquitinated TP53 translocates to the cytosol
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-6804757] Regulation of TP53 Degradation - Homo sapiens
input	[Complex:R-HSA-3209186] PolyUb-TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6793677] An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 [LiteratureReference:6793680] The MDM2 RING-finger domain is required to promote p53 nuclear export
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Ubiquitinated TP53 translocates to the cytosol
orthologousEvent	[Reaction:R-XTR-6793685] Ubiquitinated TP53 translocates to the cytosol - Xenopus tropicalis [Reaction:R-DME-6793685] Ubiquitinated TP53 translocates to the cytosol - Drosophila melanogaster [Reaction:R-DRE-6793685] Ubiquitinated TP53 translocates to the cytosol - Danio rerio [Reaction:R-SSC-6793685] Ubiquitinated TP53 translocates to the cytosol - Sus scrofa [Reaction:R-BTA-6793685] Ubiquitinated TP53 translocates to the cytosol - Bos taurus [Reaction:R-CFA-6793685] Ubiquitinated TP53 translocates to the cytosol - Canis familiaris [Reaction:R-RNO-6793685] Ubiquitinated TP53 translocates to the cytosol - Rattus norvegicus [Reaction:R-MMU-6793685] Ubiquitinated TP53 translocates to the cytosol - Mus musculus
output	[Complex:R-HSA-8856287] PolyUb-TP53 Tetramer [cytosol]
precedingEvent	[Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6793685
summation	[Summation:6795301] Upon MDM2-mediated ubiquitination, TP53 is exported from the...
updateTrackers	[UpdateTracker:9782760] Update Tracker - [Reaction:6793685] Ubiquitinated TP53 translocates to the cytosol - v58:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782760] Update Tracker - [Reaction:6793685] Ubiquitinated TP53 translocates to the cytosol - v58:[modifyText]
(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53 [Pathway:R-HSA-6804757] Regulation of TP53 Degradation