Reactome | Ubiquitinated TP53 translocates to the cytosol

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Ubiquitinated TP53 translocates to the cytosol Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10622412
displayName	Ubiquitinated TP53 translocates to the cytosol
eventOf	[Pathway:R-DRE-69541] Stabilization of p53 - Danio rerio [Pathway:R-DRE-6804757] Regulation of TP53 Degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6793685] Ubiquitinated TP53 translocates to the cytosol - Homo sapiens
input	[Complex:R-DRE-3209186] PolyUb-TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitinated TP53 translocates to the cytosol
output	[Complex:R-DRE-8856287] PolyUb-TP53 Tetramer [cytosol]
precedingEvent	[Reaction:R-DRE-6804879] MDM2 ubiquitinates TP53 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6793685
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-69541] Stabilization of p53 [Pathway:R-DRE-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-6793685] Ubiquitinated TP53 translocates to the cytosol

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