Ubiquitinated TP53 translocates to the cytosol

Stable Identifier
R-HSA-6793685
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Ubiquitinated TP53 translocates to the cytosol
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Upon MDM2-mediated ubiquitination, TP53 is exported from the nucleus to the cytosol. TP53 nuclear export requires the nuclear export sequence (NES) of TP53, but not the NES of MDM2 (Boyd et al. 2000. Geyer et al. 2000).
Literature References
PubMed ID Title Journal Year
10980695 An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

Boyd, SD, Tsai, KY, Jacks, T

Nat. Cell Biol. 2000
10980696 The MDM2 RING-finger domain is required to promote p53 nuclear export

Maki, CG, Yu, ZK, Geyer, RK

Nat. Cell Biol. 2000
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-03)
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