Reactome | 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA

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45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA Show undefined attributes

authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId	6791228
displayName	45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791221] 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA - Homo sapiens
input	[Complex:R-HSA-6791211] 45S pre-rRNA:SSU processome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6791175] Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis [LiteratureReference:6791149] Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [LiteratureReference:8855026] 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
output	[Complex:R-HSA-6791185] 30S pre-rRNA:SSU processome [nucleoplasm] [GenomeEncodedEntity:R-HSA-6791200] 32S pre-rRNA [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6791227] 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA - Homo sapiens
regulatedBy	[Requirement:R-HSA-8948999] Requirement by 'RBM28 [nucleoplasm]' [Requirement:R-HSA-8949005] Requirement by 'EXOSC10 [nucleoplasm]' [Requirement:R-HSA-8949007] Requirement by 'NOL12 [nucleoplasm]' [Requirement:R-HSA-8949015] Requirement by 'RRP1 [nucleoplasm]' [Requirement:R-HSA-8949025] Requirement by 'BOP1 [nucleoplasm]' [Requirement:R-HSA-8949041] Requirement by 'XRN2 [nucleoplasm]'
regulationReference	[RegulationReference:9642002] Requirement by 'NOL12 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9642123] Requirement by 'RBM28 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9642244] Requirement by 'XRN2 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9642387] Requirement by 'BOP1 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9642554] Requirement by 'RRP1 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing [RegulationReference:9642818] Requirement by 'EXOSC10 [nucleoplasm]' Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6791228
summation	[Summation:6797213] An unknown endonuclease cleaves at site 2 (also called site ...
updateTrackers	[UpdateTracker:9781688] Update Tracker - [BlackBoxEvent:6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA - v60:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781688] Update Tracker - [BlackBoxEvent:6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA - v60:[addRegulator]
(hasEvent)	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol
(precedingEvent)	[BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA [BlackBoxEvent:R-HSA-6791221] 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA

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