Reactome | Major pathway of rRNA processing in the nucleolus and cytosol

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Major pathway of rRNA processing in the nucleolus and cytosol Show undefined attributes

authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId	6791226
displayName	Major pathway of rRNA processing in the nucleolus and cytosol
doi	10.3180/r-hsa-6791226.1
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf	[Pathway:R-HSA-8868773] rRNA processing in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17838] rRNA processing
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-6791227] 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791221] 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Homo sapiens [BlackBoxEvent:R-HSA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:6790800] An overview of pre-ribosomal RNA processing in eukaryotes [LiteratureReference:6791151] Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand? [LiteratureReference:6791155] The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors [LiteratureReference:6792643] The nucleolus: structure/function relationship in RNA metabolism [LiteratureReference:6790796] The small subunit processome in ribosome biogenesis?progress and prospects [LiteratureReference:6798730] Duration of the first steps of the human rRNA processing [LiteratureReference:6807322] Non-isotopic mapping of ribosomal RNA synthesis and processing in the nucleolus [LiteratureReference:6790852] A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis [LiteratureReference:8855026] 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors [LiteratureReference:8855029] A protein interaction map of the LSU processome
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Major pathway of rRNA processing in the nucleolus and cytosol
orthologousEvent	[Pathway:R-SCE-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Saccharomyces cerevisiae [Pathway:R-SPO-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Schizosaccharomyces pombe [Pathway:R-DDI-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Dictyostelium discoideum [Pathway:R-CEL-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Caenorhabditis elegans [Pathway:R-DME-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Drosophila melanogaster [Pathway:R-GGA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Gallus gallus [Pathway:R-XTR-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Xenopus tropicalis [Pathway:R-DRE-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Danio rerio [Pathway:R-SSC-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Sus scrofa [Pathway:R-BTA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Bos taurus [Pathway:R-CFA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Canis familiaris [Pathway:R-RNO-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Rattus norvegicus [Pathway:R-MMU-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Mus musculus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6791226
summation	[Summation:6791224] In humans, a 47S precursor rRNA (pre-rRNA) is transcribed by...
updateTrackers	[UpdateTracker:9777306] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v72:[updateContainedRLE] [UpdateTracker:9783198] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v57:[updateContainedRLE] [UpdateTracker:9782006] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v60:[updateContainedRLE] [UpdateTracker:9782893] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v58:[updateContainedRLE] [UpdateTracker:9780446] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v63:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9777306] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v72:[updateContainedRLE]
[UpdateTracker:9783198] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v57:[updateContainedRLE]
[UpdateTracker:9782006] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v60:[updateContainedRLE]
[UpdateTracker:9782893] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v58:[updateContainedRLE]
[UpdateTracker:9780446] Update Tracker - [Pathway:6791226] Major pathway of rRNA processing in the nucleolus and cytosol - v63:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-8868773] rRNA processing in the nucleus and cytosol

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