Reactome | 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol

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18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol Show undefined attributes

authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
catalystActivity	[CatalystActivity:6791528] RNA endonuclease activity of NOB1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643798] endoribonuclease activity of NOB1 [cytosol] Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId	6791223
displayName	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Homo sapiens
input	[Complex:R-HSA-6791531] 18SE pre-40S particle [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6791522] RIOK3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6791579] Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals [LiteratureReference:6791557] Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2 [LiteratureReference:6791576] The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits [LiteratureReference:6791523] Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA [LiteratureReference:6797209] Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells [LiteratureReference:6790972] WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA [LiteratureReference:6797220] CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation [LiteratureReference:6797241] RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1 [LiteratureReference:6790848] Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assemblies
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
orthologousEvent	[BlackBoxEvent:R-MMU-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Mus musculus [BlackBoxEvent:R-RNO-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Rattus norvegicus [BlackBoxEvent:R-BTA-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Bos taurus [BlackBoxEvent:R-DRE-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Danio rerio [BlackBoxEvent:R-DDI-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Dictyostelium discoideum [BlackBoxEvent:R-SPO-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Schizosaccharomyces pombe [BlackBoxEvent:R-SCE-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Saccharomyces cerevisiae
output	[Complex:R-HSA-72392] 40S ribosomal complex [cytosol] [EntityWithAccessionedSequence:R-HSA-6791518] BYSL [cytosol] [EntityWithAccessionedSequence:R-HSA-380315] CSNK1D [cytosol] [EntityWithAccessionedSequence:R-HSA-205877] CSNK1E [cytosol] [EntityWithAccessionedSequence:R-HSA-6791520] LTV1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791524] NOB1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791509] PNO1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791525] RIOK1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791533] RIOK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791522] RIOK3 [cytosol] [EntityWithAccessionedSequence:R-HSA-6791570] TSR1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA - Homo sapiens
regulatedBy	[Requirement:R-HSA-8949027] Requirement by 'WBSCR22 [nucleoplasm]' [Requirement:R-HSA-9023927] Requirement by 'CSNK1E [cytosol]' [Requirement:R-HSA-9023929] Requirement by 'CSNK1D [cytosol]'
regulationReference	[RegulationReference:9641544] Requirement by 'CSNK1E [cytosol]' CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation [RegulationReference:9642617] Requirement by 'CSNK1D [cytosol]' CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation [RegulationReference:9642785] Requirement by 'WBSCR22 [nucleoplasm]' WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6791223
summation	[Summation:6791530] Exonuclease activity of the exosome (Preti et al. 2013) and ...
updateTrackers	[UpdateTracker:9780483] Update Tracker - [BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - v63:[addRegulator, removeCatalystActivity] [UpdateTracker:9781812] Update Tracker - [BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - v60:[addRegulator]

Referrals

(hasEvent)

[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol

(updatedInstance)

[UpdateTracker:9780483] Update Tracker - [BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - v63:[addRegulator, removeCatalystActivity]
[UpdateTracker:9781812] Update Tracker - [BlackBoxEvent:6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - v60:[addRegulator]

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