Reactome | DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851

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DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 Show undefined attributes

authored	[InstanceEdit:6790955] May, Bruce, 2015-08-15
catalystActivity	[CatalystActivity:6790970] rRNA (adenine-N6,N6-)-dimethyltransferase activity of DIMT1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643093] rRNA (adenine-N6,N6-)-dimethyltransferase activity of DIMT1 [nucleoplasm] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790964] May, Bruce, 2015-08-16
dbId	6790994
displayName	DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
edited	[InstanceEdit:6790955] May, Bruce, 2015-08-15
eventOf	[Pathway:R-HSA-6790901] rRNA modification in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161509] rRNA methylation
input	4 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [GenomeEncodedEntity:R-HSA-6790998] pre-rRNA containing 7-methylG-1639 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6790968] The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
output	[GenomeEncodedEntity:R-HSA-6791006] 21S pre-rRNA containing 7-methylG-1639, 6-dimethylA-1850,1851 [nucleoplasm] 4 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6790982] WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639 - Homo sapiens
regulatedBy	[Requirement:R-HSA-8949037] Requirement by 'PNO1 [nucleoplasm]'
regulationReference	[RegulationReference:9642606] Requirement by 'PNO1 [nucleoplasm]' The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6790994
summation	[Summation:6797238] DIMT1 (DIMT1L) dimethylates the N(6) position of adenosine-1...
updateTrackers	[UpdateTracker:9781899] Update Tracker - [Reaction:6790994] DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 - v60:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781899] Update Tracker - [Reaction:6790994] DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851 - v60:[addRegulator]
(hasEvent)	[Pathway:R-HSA-6790901] rRNA modification in the nucleus and cytosol

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