Reactome | Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides

Schema > Reaction > Entries

Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides Show undefined attributes

authored	[InstanceEdit:6790903] May, Bruce, 2015-08-12
catalystActivity	[CatalystActivity:6790908] O-methyltransferase activity of Box C/D snoRNP [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6790904] May, Bruce, 2015-08-15
dbId	6790907
displayName	Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides
edited	[InstanceEdit:6790903] May, Bruce, 2015-08-12
eventOf	[Pathway:R-HSA-6790901] rRNA modification in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258833] rRNA 2'-O-methylation
inferredFrom	[Reaction:R-SCE-6793739] Box C/D snoRNP methylates ribonucleotides in pre-rRNA - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-74978] nascent pre-rRNA transcript [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6790681] snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs [LiteratureReference:6790814] A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP [LiteratureReference:6790999] Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem [LiteratureReference:6793744] SnoRNA-guided ribose methylation of rRNA: structural features of the guide RNA duplex influencing the extent of the reaction [LiteratureReference:6790793] A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly [LiteratureReference:6793694] Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins [LiteratureReference:6793696] Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP [LiteratureReference:6793704] Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs [LiteratureReference:6807393] Modified Method of rRNA Structure Analysis Reveals Novel Characteristics of Box C/D RNA Analogues
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6790604] pre-rRNA containing 2'-O-methylribonucleotides [nucleoplasm]
precedingEvent	[Reaction:R-HSA-74992] Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30 [InstanceEdit:8856924] Sharma, Sunny, 2016-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6790907
summation	[Summation:6790977] The Fibrillarin (FBL) component of Box C/D small nucleolar r...

Referrals

(hasEvent)	[Pathway:R-HSA-6790901] rRNA modification in the nucleus and cytosol
(inferredTo)	[Reaction:R-SCE-6793739] Box C/D snoRNP methylates ribonucleotides in pre-rRNA