Reactome | Translesion synthesis across unhooked ICL by POLN

Schema > BlackBoxEvent > Entries

Translesion synthesis across unhooked ICL by POLN Show undefined attributes

catalystActivity	[CatalystActivity:10798648] DNA-directed DNA polymerase activity of MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10798650
displayName	Translesion synthesis across unhooked ICL by POLN
eventOf	[Pathway:R-GGA-6783310] Fanconi Anemia Pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-6786166] Translesion synthesis across unhooked ICL by POLN - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-GGA-6786156] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Translesion synthesis across unhooked ICL by POLN
output	[OtherEntity:R-ALL-5688114] Distorted dsDNA [nucleoplasm] [OtherEntity:R-ALL-75165] DNA double-strand break ends [nucleoplasm] [Complex:R-GGA-420757] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] [Complex:R-GGA-6788399] p-FA Core Complex [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-6786153] POLN [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-GGA-6786155] POLN binds ICL-DNA - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-6786166
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-6783310] Fanconi Anemia Pathway
(inferredTo)	[BlackBoxEvent:R-HSA-6786166] Translesion synthesis across unhooked ICL by POLN