Reactome | PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer

Schema > Reaction > Entries

PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer Show undefined attributes

catalystActivity	[CatalystActivity:10188522] endopeptidase activity of PCSK5 [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10188524
displayName	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
eventOf	[Pathway:R-RNO-8963889] Assembly of active LPL and LIPC lipase complexes - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Homo sapiens
input	[Complex:R-RNO-8857969] GPIHBP1:HSPG:LPL dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
output	[EntityWithAccessionedSequence:R-RNO-5216067] Gpihbp1 [plasma membrane] [SimpleEntity:R-ALL-1678620] HSPG [plasma membrane] 2 × [EntityWithAccessionedSequence:R-RNO-174605] LPL [extracellular region]
regulatedBy	[PositiveRegulation:10188519] Positive regulation by 'ANGPTL4 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6784676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8963889] Assembly of active LPL and LIPC lipase complexes
(inferredTo)	[Reaction:R-HSA-6784676] PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer

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