Reactome | PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

catalystActivity	[CatalystActivity:10524243] pyrroline-5-carboxylate reductase activity of PYCR2 decamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10524245
displayName	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
eventOf	[Pathway:R-SSC-8964539] Glutamate and glutamine metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens
input	[SimpleEntity:R-ALL-35305] 1PYR-5COOH [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)
output	[SimpleEntity:R-ALL-113538] L-Pro [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6783939
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8964539] Glutamate and glutamine metabolism
(inferredTo)	[Reaction:R-HSA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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