Reactome | ERCC5 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5689317] Formation of the pre-incision complex in GG-NER - Homo sapiens [Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens
dbId	67447
displayName	ERCC5 [nucleoplasm]
endCoordinate	1186
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-67447] ERCC5 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-67447] ERCC5 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-67447] ERCC5 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-67447] ERCC5 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-67447] ERCC5 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-67447] ercc5 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-67447] ercc5 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-67447] ERCC5 [nucleoplasm] - Gallus gallus [GenomeEncodedEntity:R-DME-67447] Ghost homologue of ERCC5 [nucleoplasm] - Drosophila melanogaster [GenomeEncodedEntity:R-CEL-67447] Ghost homologue of ERCC5 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-67447] ERCC5 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-67447] ERCC5 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-67447] ERCC5 [nucleoplasm] - Saccharomyces cerevisiae [GenomeEncodedEntity:R-PFA-67447] Ghost homologue of ERCC5 [nucleoplasm] - Plasmodium falciparum
maxDepth	1
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	ERCC5 XPG protein DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G complementing protein) (DNA excision repair protein ERCC-5) ERCC5 or XPGC Xeroderma pigmentosum group G complementing protein DNA excision repair protein ERCC-5 DNA-repair protein complementing XP-G cells DNA excision repair protein ERCC-5
producedByEvent	[Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Homo sapiens [Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P28715] UniProt:P28715 ERCC5
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-67447
startCoordinate	1
updateTrackers	[UpdateTracker:9880010] Update Tracker - [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] - v44:[modifyEndCoordinate] [UpdateTracker:9880513] Update Tracker - [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] - v45:[addName]

(updatedInstance)	[UpdateTracker:9880010] Update Tracker - [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] - v44:[modifyEndCoordinate] [UpdateTracker:9880513] Update Tracker - [EntityWithAccessionedSequence:67447] ERCC5 [nucleoplasm] - v45:[addName]
(output)	[Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER [Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER
(activeUnit)	[CatalystActivity:6782216] DNA endonuclease activity of TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [CatalystActivity:5691069] DNA endonuclease activity of GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
(hasComponent)	[Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-HSA-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm]
(input)	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site [Reaction:R-HSA-5689317] Formation of the pre-incision complex in GG-NER

ERCC5 [nucleoplasm] Show undefined attributes

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