Reactome | CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

Stable Identifier

R-HSA-5696627

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

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CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
12917691	The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination Cantarella, G, Wallach, D, Courtois, G, Chable-Bessia, C, Israel, A, Kovalenko, A	Nature	2003
12917689	CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members Ashworth, A, Farmer, H, Trompouki, E, Tsichritzis, T, Hatzivassiliou, E, Mosialos, G	Nature	2003
17981138	Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD Chang, M, Sun, SC, Wright, A, Zhang, M, Lee, AJ, Reiley, WW, Jin, W	Dev. Cell	2007