CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).

Literature References
PubMed ID Title Journal Year
12917689 CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

Trompouki, E, Hatzivassiliou, E, Tsichritzis, T, Farmer, H, Ashworth, A, Mosialos, G

Nature 2003
12917691 The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

Kovalenko, A, Chable-Bessia, C, Cantarella, G, Israel, A, Wallach, D, Courtois, G

Nature 2003
17981138 Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD

Wright, A, Reiley, WW, Chang, M, Jin, W, Lee, AJ, Zhang, M, Sun, SC

Dev. Cell 2007
Catalyst Activity

thiol-dependent deubiquitinase activity of CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]

Orthologous Events
Cite Us!