CYLD removes Lys63-linked ubiquitin chains, acting as a negative regulator of NF-kappa-B signaling (Trompouki et al. 2003). It deubiquitinates several NF-kappa-B regulators including TRAF2, TRAF6 (Kovalenko et al. 2003, Trompouki et al. 2003), IKBKG (NEMO) (Brummelkamp et al. 2003), and RIPK1 (Wright et al. 2007).
Cantarella, G, Wallach, D, Courtois, G, Chable-Bessia, C, Israel, A, Kovalenko, A
Ashworth, A, Farmer, H, Trompouki, E, Tsichritzis, T, Hatzivassiliou, E, Mosialos, G
Chang, M, Sun, SC, Wright, A, Zhang, M, Lee, AJ, Reiley, WW, Jin, W
cysteine-type deubiquitinase activity of CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol]
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