Reactome | ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

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ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA Show undefined attributes

authored	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
catalystActivity	[CatalystActivity:5695982] very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
crossReference	[DatabaseIdentifier:12667579] RHEA:54537 [DatabaseIdentifier:9865934] RHEA:54537
dbId	5695957
displayName	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA
edited	[InstanceEdit:5695977] Jassal, Bijay, 2015-05-26
eventOf	[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-5695985] VLCFA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5695997] Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids [LiteratureReference:5695951] The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation. [LiteratureReference:5695947] The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
orthologousEvent	[Reaction:R-DDI-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Dictyostelium discoideum [Reaction:R-DME-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Drosophila melanogaster [Reaction:R-GGA-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Gallus gallus [Reaction:R-DRE-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Danio rerio [Reaction:R-SSC-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Sus scrofa [Reaction:R-CFA-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Canis familiaris [Reaction:R-RNO-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Rattus norvegicus [Reaction:R-MMU-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-5695971] VLCFA-CoA [cytosol]
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5695957
summation	[Summation:5695962] Long-chain fatty acid-CoA ligases 1 and 2 (ACSBG1 and 2) are...

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(hasEvent)

[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs

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