Reactome | ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

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ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10297216] very long-chain fatty acid-CoA ligase activity of ACSBG1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10297218
displayName	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA
eventOf	[Pathway:R-CFA-75876] Synthesis of very long-chain fatty acyl-CoAs - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-5695985] VLCFA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-5695971] VLCFA-CoA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5695957
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-75876] Synthesis of very long-chain fatty acyl-CoAs
(inferredTo)	[Reaction:R-HSA-5695957] ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA

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