Reactome | FUCA1 hydrolyses NGP:1,6-GlcNAc

Schema > Reaction > Entries

FUCA1 hydrolyses NGP:1,6-GlcNAc Show undefined attributes

authored	[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
catalystActivity	[CatalystActivity:5693808] alpha-L-fucosidase activity of FUCA1 tetramer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
dbId	5693807
displayName	FUCA1 hydrolyses NGP:1,6-GlcNAc
edited	[InstanceEdit:5693803] Jassal, Bijay, 2015-05-18
eventOf	[Pathway:R-HSA-975578] Reactions specific to the complex N-glycan synthesis pathway - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [OtherEntity:R-ALL-6784247] NGP:1,6-GlcNAc [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5693843] Comparative and phylogenetic analysis of alpha-L-fucosidase genes [LiteratureReference:5693841] Spectrum of mutations in fucosidosis
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	FUCA1 hydrolyses NGP:1,6-GlcNAc
orthologousEvent	[Reaction:R-BTA-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Bos taurus [Reaction:R-DDI-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Dictyostelium discoideum [Reaction:R-CEL-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Caenorhabditis elegans [Reaction:R-DME-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Drosophila melanogaster [Reaction:R-GGA-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Gallus gallus [Reaction:R-XTR-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Xenopus tropicalis [Reaction:R-DRE-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Danio rerio [Reaction:R-SSC-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Sus scrofa [Reaction:R-CFA-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Canis familiaris [Reaction:R-RNO-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Rattus norvegicus [Reaction:R-MMU-5693807] FUCA1 hydrolyses NGP:1,6-GlcNAc - Mus musculus
output	[SimpleEntity:R-ALL-6784249] L-fucose [lysosomal lumen] [SimpleEntity:R-ALL-6784248] NGP [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1028788] FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693807
summation	[Summation:5693806] Tissue alpha-L-fucosidase (FUCA1) is a lysosomal enzyme that...

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[Pathway:R-HSA-975578] Reactions specific to the complex N-glycan synthesis pathway