Reactome | CHEK1 phosphorylates RAD51

Schema > Reaction > Entries

CHEK1 phosphorylates RAD51 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:182636] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5685238] Orlic-Milacic, Marija, 2015-03-26
dbId	5685230
displayName	CHEK1 phosphorylates RAD51
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Homo sapiens
followingEvent	[Reaction:R-HSA-5693561] RAD51 binds BRCA2 at resected DNA DSBs - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-62637] RAD51 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685232] The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	CHEK1 phosphorylates RAD51
negativePrecedingEvent	[NegativePrecedingEvent:9766956] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA
orthologousEvent	[Reaction:R-SCE-5685230] CHEK1 phosphorylates RAD51 - Saccharomyces cerevisiae [Reaction:R-SPO-5685230] CHEK1 phosphorylates RAD51 - Schizosaccharomyces pombe [Reaction:R-CEL-5685230] CHEK1 phosphorylates RAD51 - Caenorhabditis elegans [Reaction:R-DME-5685230] CHEK1 phosphorylates RAD51 - Drosophila melanogaster [Reaction:R-SSC-5685230] CHEK1 phosphorylates RAD51 - Sus scrofa [Reaction:R-CFA-5685230] CHEK1 phosphorylates RAD51 - Canis familiaris [Reaction:R-RNO-5685230] CHEK1 phosphorylates RAD51 - Rattus norvegicus [Reaction:R-MMU-5685230] CHEK1 phosphorylates RAD51 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5685231] p-T309-RAD51 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5685230
summation	[Summation:5685234] Activated CHEK1 phosphorylates RAD51 on threonine residue T3...

Referrals

(hasEvent)	[Pathway:R-HSA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange
(precedingEvent)	[Reaction:R-HSA-5693561] RAD51 binds BRCA2 at resected DNA DSBs