Reactome | Association of RAD52 with the RPA complex at resected DNA DSBs

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Association of RAD52 with the RPA complex at resected DNA DSBs Show undefined attributes

authored	[InstanceEdit:73965] Thompson, L, 2003-07-14 15:03:24
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693580
deleted	[Deleted:6793041] Deletion of instance: 109779 [Deleted:6793039] Deletion of instance: 83644
displayName	Association of RAD52 with the RPA complex at resected DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5685938] HDR through Single Strand Annealing (SSA) - Homo sapiens
followingEvent	[Reaction:R-HSA-5693564] Association of RAD51 with RAD52:DNA double-strand break ends - Homo sapiens
input	[Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Complex:R-HSA-5686589] p-Y104-RAD52 heptamer [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:83611] Precise binding of single-stranded DNA termini by human RAD52 protein. [LiteratureReference:5686535] Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding [LiteratureReference:5686518] BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair [LiteratureReference:5686520] Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation [LiteratureReference:5686514] Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells [LiteratureReference:5686516] WRN interacts physically and functionally with the recombination mediator protein RAD52 [LiteratureReference:5686540] Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Association of RAD52 with the RPA complex at resected DNA DSBs
negativePrecedingEvent	[NegativePrecedingEvent:9766942] Futile Cycle: Activation of CHEK1 at resected DNA DSBs [NegativePrecedingEvent:9766955] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA
orthologousEvent	[Reaction:R-GGA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Gallus gallus [Reaction:R-DRE-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Danio rerio [Reaction:R-SSC-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Sus scrofa [Reaction:R-BTA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Bos taurus [Reaction:R-CFA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Canis familiaris [Reaction:R-RNO-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Rattus norvegicus [Reaction:R-MMU-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Mus musculus
output	[Complex:R-HSA-5693547] p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5685156] ATR phosphorylates RPA2 - Homo sapiens [Reaction:R-HSA-5686587] ABL1 phosphorylates RAD52 - Homo sapiens
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693580
summation	[Summation:5693559] RAD52 heptamers bind 3' overhanging ssDNA at resected DNA do...
updateTrackers	[UpdateTracker:9775509] Update Tracker - [Reaction:5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - v78:[modifyText]

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(updatedInstance)	[UpdateTracker:9775509] Update Tracker - [Reaction:5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - v78:[modifyText]
(replacementInstances)	[Deleted:6793041] Deletion of instance: 109779 [Deleted:6793039] Deletion of instance: 83644
(hasEvent)	[Pathway:R-HSA-5685938] HDR through Single Strand Annealing (SSA)
(precedingEvent)	[Reaction:R-HSA-5693564] Association of RAD51 with RAD52:DNA double-strand break ends

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