Reactome | ATR phosphorylates RPA2

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ATR phosphorylates RPA2 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5685163] protein serine/threonine kinase activity of ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5685154] Orlic-Milacic, Marija, 2015-03-25
dbId	5685156
displayName	ATR phosphorylates RPA2
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Reaction:R-HSA-5684882] CHEK1 is recruited to resected DNA DSBs - Homo sapiens [Reaction:R-HSA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5685039] ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:391632] Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair [LiteratureReference:5685173] Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress [LiteratureReference:5685175] Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	ATR phosphorylates RPA2
orthologousEvent	[Reaction:R-CEL-5685156] ATR phosphorylates RPA2 - Caenorhabditis elegans [Reaction:R-DME-5685156] ATR phosphorylates RPA2 - Drosophila melanogaster [Reaction:R-MMU-5685156] ATR phosphorylates RPA2 - Mus musculus [Reaction:R-GGA-5685156] ATR phosphorylates RPA2 - Gallus gallus [Reaction:R-XTR-5685156] ATR phosphorylates RPA2 - Xenopus tropicalis [Reaction:R-SSC-5685156] ATR phosphorylates RPA2 - Sus scrofa [Reaction:R-BTA-5685156] ATR phosphorylates RPA2 - Bos taurus [Reaction:R-CFA-5685156] ATR phosphorylates RPA2 - Canis familiaris [Reaction:R-RNO-5685156] ATR phosphorylates RPA2 - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5685011] ATR activation at DNA DSBs - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5685156
summation	[Summation:5685182] Activated ATR phosphorylates the RPA2 subunit of the RPA com...

Referrals

(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[NegativePrecedingEvent:9766939] Futile Cycle: ATR phosphorylates RPA2 [Reaction:R-HSA-5684882] CHEK1 is recruited to resected DNA DSBs [Reaction:R-HSA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs

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