Reactome | HDR through Single Strand Annealing (SSA)

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HDR through Single Strand Annealing (SSA) Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
created	[InstanceEdit:5685937] Orlic-Milacic, Marija, 2015-03-30
dbId	5685938
deleted	[Deleted:6793537] Deletion of instance: 76003
displayName	HDR through Single Strand Annealing (SSA)
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-75998] Formation of RAD52 heptameric ring structure complexes - Homo sapiens [Reaction:R-HSA-5686587] ABL1 phosphorylates RAD52 - Homo sapiens [Reaction:R-HSA-5693580] Association of RAD52 with the RPA complex at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-5693564] Association of RAD51 with RAD52:DNA double-strand break ends - Homo sapiens [Reaction:R-HSA-5686642] RAD52 promotes single strand annealing at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA - Homo sapiens [Reaction:R-HSA-5686657] ERCC1:XPF cleaves flaps generated by SSA - Homo sapiens [BlackBoxEvent:R-HSA-9980021] LIG1 binds SSA sites - Homo sapiens [BlackBoxEvent:R-HSA-5686663] Completion of SSA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5686000] DNA end resection by CtIP and exonuclease 1 prevents genomic instability [LiteratureReference:913336] Human CtIP promotes DNA end resection [LiteratureReference:5684117] CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle [LiteratureReference:5685998] BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair [LiteratureReference:5685975] DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells [LiteratureReference:5687734] Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome [LiteratureReference:176216] Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes [LiteratureReference:391632] Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair [LiteratureReference:5685173] Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress [LiteratureReference:5686535] Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding [LiteratureReference:5686540] Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA [LiteratureReference:83611] Precise binding of single-stranded DNA termini by human RAD52 protein. [LiteratureReference:109575] Structure of the single-strand annealing domain of human RAD52 protein. [LiteratureReference:217133] Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl [LiteratureReference:83613] Visualisation of human rad52 protein and its complexes with hRad51 and DNA. [LiteratureReference:5686569] Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks [LiteratureReference:5686553] Genetic steps of mammalian homologous repair with distinct mutagenic consequences [LiteratureReference:5686669] The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells [LiteratureReference:5686653] Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HDR through Single Strand Annealing (SSA)
orthologousEvent	[Pathway:R-DDI-5685938] HDR through Single Strand Annealing (SSA) - Dictyostelium discoideum [Pathway:R-MMU-5685938] HDR through Single Strand Annealing (SSA) - Mus musculus [Pathway:R-RNO-5685938] HDR through Single Strand Annealing (SSA) - Rattus norvegicus [Pathway:R-CFA-5685938] HDR through Single Strand Annealing (SSA) - Canis familiaris [Pathway:R-BTA-5685938] HDR through Single Strand Annealing (SSA) - Bos taurus [Pathway:R-SSC-5685938] HDR through Single Strand Annealing (SSA) - Sus scrofa [Pathway:R-DRE-5685938] HDR through Single Strand Annealing (SSA) - Danio rerio [Pathway:R-XTR-5685938] HDR through Single Strand Annealing (SSA) - Xenopus tropicalis [Pathway:R-GGA-5685938] HDR through Single Strand Annealing (SSA) - Gallus gallus [Pathway:R-SPO-5685938] HDR through Single Strand Annealing (SSA) - Schizosaccharomyces pombe [Pathway:R-SCE-5685938] HDR through Single Strand Annealing (SSA) - Saccharomyces cerevisiae
precedingEvent	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5685938
summation	[Summation:5687793] Homology directed repair (HDR) through single strand anneali...
updateTrackers	[UpdateTracker:9776561] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v75:[updateContainedRLE] [UpdateTracker:9984713] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v96:[removeHasEvent] [UpdateTracker:9775551] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v78:[modifyText, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
(replacementInstances)	[Deleted:6793537] Deletion of instance: 76003
(updatedInstance)	[UpdateTracker:9776561] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v75:[updateContainedRLE] [UpdateTracker:9984713] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v96:[removeHasEvent] [UpdateTracker:9775551] Update Tracker - [Pathway:5685938] HDR through Single Strand Annealing (SSA) - v78:[modifyText, updateContainedRLE]

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