Reactome | ALD3A1 oxidises 4HPCP to CXPA

ALD3A1 oxidises 4HPCP to CXPA

Stable Identifier

R-HSA-5692283

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in cancer chemo-resistance by oxidising activated forms of oxazaphosphorine drugs such as 4-hydroperoxycyclophosphamide (4HPCP) to the inactive metabolite carboxy-phosphamide (CXPA) (Moreb et al. 2007, Parajuli et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24677340	Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity Parajuli, B, Georgiadis, TM, Fishel, ML, Hurley, TD	Chembiochem	2014
16614850	RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide Moreb, JS, Mohuczy, D, Muhoczy, D, Ostmark, B, Zucali, JR	Cancer Chemother. Pharmacol.	2007