Reactome | CD22 binds B-cell receptor

CD22 binds B-cell receptor

Stable Identifier

R-HSA-5690740

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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Physical association of CD22 with the BCR seems to have direct involvement in the regulation of BCR signalling, as antibody-mediated clustering of CD22 with the BCR leads to dampened signaling (Smith et al. 1998), and evidence of their association has been obtained by confocal microscopy, coimmunoprecipitation and chemical crossing (Zhang et al. 2004, Phee et al. 2001, Peaker et al. 1993, Law et al. 1994, Leprince et al. 1993, Collins et al. 2006). Forced ligation of CD22 to the BCR dramatically increases CD22 phosphorylation and suppression of BCR signalling (Macauley, 2013). This is relevant to suppression of BCR signalling to membrane antigens on B cells that contain self sialic acids (Lanoue, 2002; Macauley 2013). CD22 ligand binding modulates its activity as a negative regulator of B cell signalling.

Literature References

PubMed ID	Title	Journal	Year
8475064	CD22 associates with the human surface IgM-B-cell antigen receptor complex Leprince, C, Draves, KE, Geahlen, RL, Ledbetter, JA, Clark, EA	Proc. Natl. Acad. Sci. U.S.A.	1993
7561031	Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells Law, CL, Aruffo, A, Chandran, KA, Doty, RT, Clark, EA	J. Immunol.	1995
11994425	Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling Jin, L, McLean, PA, Neel, BG, Wortis, HH	J. Exp. Med.	2002
7706301	Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin Hanasaki, K, Powell, LD, Varki, A	J. Biol. Chem.	1995