Reactome | PKA phosphorylates MAPKAPK5

Schema > Reaction > Entries

PKA phosphorylates MAPKAPK5 Show undefined attributes

authored	[InstanceEdit:5686894] Rothfels, Karen, 2015-04-02
catalystActivity	[CatalystActivity:163675] cAMP-dependent protein kinase activity of Protein Kinase A, catalytic subunits [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687087] Rothfels, Karen, 2015-04-06
dbId	5687088
displayName	PKA phosphorylates MAPKAPK5
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5687123] p-S115 MAPKAPK5 translocates to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2562517] MAPKAPK5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686819] Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5 [LiteratureReference:5686834] PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5 [LiteratureReference:5686957] Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function [LiteratureReference:5686970] Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PKA phosphorylates MAPKAPK5
orthologousEvent	[Reaction:R-PFA-5687088] PKA phosphorylates MAPKAPK5 - Plasmodium falciparum [Reaction:R-GGA-5687088] PKA phosphorylates MAPKAPK5 - Gallus gallus [Reaction:R-DRE-5687088] PKA phosphorylates MAPKAPK5 - Danio rerio [Reaction:R-SSC-5687088] PKA phosphorylates MAPKAPK5 - Sus scrofa [Reaction:R-BTA-5687088] PKA phosphorylates MAPKAPK5 - Bos taurus [Reaction:R-RNO-5687088] PKA phosphorylates MAPKAPK5 - Rattus norvegicus [Reaction:R-MMU-5687088] PKA phosphorylates MAPKAPK5 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5687026] p-S115 MAPKAPK5 [nucleoplasm]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687088
summation	[Summation:5686993] MAPKAPK5 is phosphorylated at serine 115 by the catalytic su...

Referrals

(hasEvent)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-5687123] p-S115 MAPKAPK5 translocates to the cytosol