Reactome | PKA phosphorylates MAPKAPK5

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PKA phosphorylates MAPKAPK5 Show undefined attributes

catalystActivity	[CatalystActivity:10406449] cAMP-dependent protein kinase activity of Protein Kinase A, catalytic subunits [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10406451
displayName	PKA phosphorylates MAPKAPK5
eventOf	[Pathway:R-BTA-5687128] MAPK6/MAPK4 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-5687123] p-S115 MAPKAPK5 translocates to the cytosol - Bos taurus
inferredFrom	[Reaction:R-HSA-5687088] PKA phosphorylates MAPKAPK5 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-2562517] MAPKAPK5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PKA phosphorylates MAPKAPK5
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-5687026] phospho-MAPKAPK5 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5687088
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5687128] MAPK6/MAPK4 signaling
(precedingEvent)	[BlackBoxEvent:R-BTA-5687123] p-S115 MAPKAPK5 translocates to the cytosol
(inferredTo)	[Reaction:R-HSA-5687088] PKA phosphorylates MAPKAPK5

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