Reactome | NAPSA, CTSH, PGA3-5 cleave pro-SFTPC

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NAPSA, CTSH, PGA3-5 cleave pro-SFTPC Show undefined attributes

authored	[InstanceEdit:5685873] Jassal, Bijay, 2015-03-30
catalystActivity	[CatalystActivity:5685879] peptidase activity of NAPSA, CTSH, PGA3-5 [multivesicular body lumen]
category	transition
compartment	[Compartment:3828046] multivesicular body lumen
created	[InstanceEdit:5685873] Jassal, Bijay, 2015-03-30
dbId	5685902
displayName	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
edited	[InstanceEdit:5685873] Jassal, Bijay, 2015-03-30
eventOf	[Pathway:R-HSA-5683826] Surfactant metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-5685882] H2O [multivesicular body lumen] [EntityWithAccessionedSequence:R-HSA-5685298] pro-SFTPC [multivesicular body lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685892] Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas [LiteratureReference:5685907] Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms [LiteratureReference:5685912] Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase [LiteratureReference:5685896] A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
orthologousEvent	[Reaction:R-XTR-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Xenopus tropicalis [Reaction:R-SSC-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Sus scrofa [Reaction:R-BTA-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Bos taurus [Reaction:R-CFA-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Canis familiaris [Reaction:R-RNO-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Rattus norvegicus [Reaction:R-MMU-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5685899] SFTPC(24-58) [multivesicular body lumen] [EntityWithAccessionedSequence:R-HSA-5685871] SFTPC(59-197) [multivesicular body lumen]
precedingEvent	[BlackBoxEvent:R-HSA-5684868] pro-SFTPC translocates from ER membrane to multivesicle body - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791021] D'Eustachio, Peter, 2015-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5685902
summation	[Summation:5685876] In the multivesicular body, surfactant precursor protein pro...

Referrals

(hasEvent)

[Pathway:R-HSA-5683826] Surfactant metabolism