NAPSA, CTSH, PGA3-5 cleave pro-SFTPC

Stable Identifier
Reaction [transition]
Homo sapiens
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In the multivesicular body, surfactant precursor protein pro-SFTPC is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1988). The resultant mature peptide SFTPC (chain 24-58) is trafficked to lamellar bodies.
Literature References
PubMed ID Title Journal Year
2515193 A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins

Takahashi, K, Kageyama, T, Athauda, SB, Tanji, M

J. Biochem. 1989
2587265 Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase

Gassen, HG, Fuchs, R

Nucleic Acids Res. 1989
3366248 Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms

Johansson, J, Robertson, B, Jörnvall, H, Christensen, N, Eklund, A, Curstedt, T

FEBS Lett. 1988
10580105 Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

Arnott, D, Ueno, T, Saito, S, Bergman, T, Appella, E, Bergman, A, Auer, G, Sakaguchi, K, Chuman, Y, Alaiya, AA, Jörnvall, H, Linder, S, Franzén, B

FEBS Lett. 1999
Catalyst Activity

peptidase activity of NAPSA, CTSH, PGA3-5 [multivesicular body lumen]

Orthologous Events
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