Reactome | PIAS4 SUMOylates MDC1

PIAS4 SUMOylates MDC1

Stable Identifier

R-HSA-5684052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS4 SUMOylates MDC1 at lysine residue K1840. The exact timing and regulation of this modification is not known (Luo et al. 2012, Yin et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22635276	Sumoylation of MDC1 is important for proper DNA damage response Luo, K, Zhang, H, Wang, L, Yuan, J, Lou, Z	EMBO J.	2012
22661230	SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage Yin, Y, Seifert, A, Chua, JS, Maure, JF, Golebiowski, F, Hay, RT	Genes Dev.	2012

Participants

Input

Output

Participant Of

hasEvent

Processing of DNA double-strand break ends

Catalyst Activity

Title

SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]

Physical Entity

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]

Activity

SUMO transferase activity (0019789)

Orthologous Events

PIAS4 SUMOylates MDC1 (Canis familiaris)

PIAS4 SUMOylates MDC1 (Danio rerio)

PIAS4 SUMOylates MDC1 (Gallus gallus)

PIAS4 SUMOylates MDC1 (Mus musculus)

PIAS4 SUMOylates MDC1 (Rattus norvegicus)

PIAS4 SUMOylates MDC1 (Sus scrofa)

PIAS4 SUMOylates MDC1 (Xenopus tropicalis)