Reactome | WHSC1 binds DNA DSBs

Schema > Reaction > Entries

WHSC1 binds DNA DSBs Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10519563
displayName	WHSC1 binds DNA DSBs
eventOf	[Pathway:R-SSC-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5682983] ATM phosphorylates WHSC1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-5682967] WHSC1 binds DNA DSBs - Homo sapiens
input	[Complex:R-SSC-5682530] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-1183215] NSD2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	WHSC1 binds DNA DSBs
output	[Complex:R-SSC-5682968] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5693536] ATM phosphorylates MDC1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5682967
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-SSC-5682983] ATM phosphorylates WHSC1
(inferredTo)	[Reaction:R-HSA-5682967] WHSC1 binds DNA DSBs