The recruitment of RNF168, an E3 ubiquitin ligase, to DNA do...

created [InstanceEdit:5682932] Orlic-Milacic, Marija, 2015-03-11
dbId 5682914
displayName The recruitment of RNF168, an E3 ubiquitin ligase, to DNA do...
modified [InstanceEdit:9750854] Orlic-Milacic, Marija, 2021-08-16
schemaClass Summation
text The recruitment of RNF168, an E3 ubiquitin ligase, to DNA double-strand breaks (DSBs) is facilitated by the interaction of RNF168 with the UBE2N:UBE2V2 (UBC13:MMS2) complex, which serves as the E2 ubiquitin ligase for both RNF8 and RNF168. In addition, because the two RNF168 ubiquitin interaction motifs (UIMs) are needed for the accumulation of RNF168 at DSBs, the initial ubiquitination of H2AFX (H2AX) histones by RNF8 is likely involved in RNF168 recruitment to DSBs. Inactivating mutations in both RNF168 alleles are responsible for the RIDDLE (radiosensitivity, immunodeficiency, dysmorphic features and learning difficulties) syndrome (Stewart et al. 2009, Doil et al. 2009, Bekker-Jensen et al. 2010, Campbell et al. 2012, Mattiroli et al. 2012).
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