Reactome | MRN complex bound to shortened telomeres recruits ATM

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MRN complex bound to shortened telomeres recruits ATM Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682019] Orlic-Milacic, Marija, 2015-03-04
dbId	5682018
displayName	MRN complex bound to shortened telomeres recruits ATM
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-6792712] KAT5 acetylates ATM at shortened telomeres - Homo sapiens
input	[Complex:R-HSA-5682037] ATM dimer:KAT5 [nucleoplasm] [Complex:R-HSA-5682022] Shortened telomere:MRN [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:912403] ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex [LiteratureReference:3785736] MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control [LiteratureReference:3785780] p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	MRN complex bound to shortened telomeres recruits ATM
orthologousEvent	[Reaction:R-DME-5682018] MRN complex bound to shortened telomeres recruits ATM - Drosophila melanogaster [Reaction:R-GGA-5682018] MRN complex bound to shortened telomeres recruits ATM - Gallus gallus [Reaction:R-DRE-5682018] MRN complex bound to shortened telomeres recruits ATM - Danio rerio [Reaction:R-SSC-5682018] MRN complex bound to shortened telomeres recruits ATM - Sus scrofa [Reaction:R-BTA-5682018] MRN complex bound to shortened telomeres recruits ATM - Bos taurus [Reaction:R-CFA-5682018] MRN complex bound to shortened telomeres recruits ATM - Canis familiaris [Reaction:R-RNO-5682018] MRN complex bound to shortened telomeres recruits ATM - Rattus norvegicus [Reaction:R-MMU-5682018] MRN complex bound to shortened telomeres recruits ATM - Mus musculus
output	[Complex:R-HSA-5682021] Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5682020] MRN complex binds shortened telomeres - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682018
summation	[Summation:5682023] Activation of ATM kinase in response to shortened telomeres ...
updateTrackers	[UpdateTracker:9784162] Update Tracker - [Reaction:5682018] MRN complex bound to shortened telomeres recruits ATM - v54:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9784162] Update Tracker - [Reaction:5682018] MRN complex bound to shortened telomeres recruits ATM - v54:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-6792712] KAT5 acetylates ATM at shortened telomeres