Reactome | KAT5 acetylates ATM at shortened telomeres

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KAT5 acetylates ATM at shortened telomeres Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:6792704] acetyltransferase activity of Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6792702] Orlic-Milacic, Marija, 2015-08-25
dbId	6792712
displayName	KAT5 acetylates ATM at shortened telomeres
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:6792641] Orlic-Milacic, Marija, 2015-08-25
eventOf	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-5682026] MRN bound to shortened telomeres activates ATM - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-HSA-5682021] Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682041] A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM [LiteratureReference:5682032] DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity [LiteratureReference:5682049] Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 [LiteratureReference:5682136] HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response [LiteratureReference:6792708] Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	KAT5 acetylates ATM at shortened telomeres
orthologousEvent	[Reaction:R-SCE-6792712] KAT5 acetylates ATM at shortened telomeres - Saccharomyces cerevisiae [Reaction:R-SPO-6792712] KAT5 acetylates ATM at shortened telomeres - Schizosaccharomyces pombe [Reaction:R-DDI-6792712] KAT5 acetylates ATM at shortened telomeres - Dictyostelium discoideum [Reaction:R-DME-6792712] KAT5 acetylates ATM at shortened telomeres - Drosophila melanogaster [Reaction:R-GGA-6792712] KAT5 acetylates ATM at shortened telomeres - Gallus gallus [Reaction:R-DRE-6792712] KAT5 acetylates ATM at shortened telomeres - Danio rerio [Reaction:R-SSC-6792712] KAT5 acetylates ATM at shortened telomeres - Sus scrofa [Reaction:R-BTA-6792712] KAT5 acetylates ATM at shortened telomeres - Bos taurus [Reaction:R-CFA-6792712] KAT5 acetylates ATM at shortened telomeres - Canis familiaris [Reaction:R-RNO-6792712] KAT5 acetylates ATM at shortened telomeres - Rattus norvegicus [Reaction:R-MMU-6792712] KAT5 acetylates ATM at shortened telomeres - Mus musculus
output	2 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm] [Complex:R-HSA-6792710] Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5682018] MRN complex bound to shortened telomeres recruits ATM - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6806897] Du, Fengxia, 2015-09-16 [InstanceEdit:6806895] Sun, Yingli, 2015-09-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6792712
summation	[Summation:6792701] The histone acetyltransferase Tip60 (KAT5), in addition to f...
updateTrackers	[UpdateTracker:9783860] Update Tracker - [Reaction:6792712] KAT5 acetylates ATM at shortened telomeres - v55:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783860] Update Tracker - [Reaction:6792712] KAT5 acetylates ATM at shortened telomeres - v55:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-5682026] MRN bound to shortened telomeres activates ATM

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