Reactome | MRN complex bound to shortened telomeres recruits ATM

MRN complex bound to shortened telomeres recruits ATM

Stable Identifier

R-HSA-5682018

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MRN complex bound to shortened telomeres recruits ATM

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Activation of ATM kinase in response to shortened telomeres requires association of ATM dimers with the MRN complex bound to DNA ends. MRN subunit RAD50 is essential for ATM dimer binding (Lee and Paull 2005, Wu et al. 2007). Dissociation of the shelterin complex from telomeres activates ATM (Karlseder et al. 1999), consistent with a mutually exclusive binding of shelterin and MRN to telomeric DNA (Wu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
15790808	ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Lee, JH, Paull, TT	Science	2005
10037601	p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 Karlseder, J, Broccoli, D, Dai, Y, Hardy, S, de Lange, T	Science	1999
17694070	MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control Wu, Y, Xiao, S, Zhu, XD	Nat. Struct. Mol. Biol.	2007