MRN complex bound to shortened telomeres recruits ATM

Stable Identifier
Reaction [binding]
Homo sapiens
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Activation of ATM kinase in response to shortened telomeres requires association of ATM dimers with the MRN complex bound to DNA ends. MRN subunit RAD50 is essential for ATM dimer binding (Lee and Paull 2005, Wu et al. 2007). Dissociation of the shelterin complex from telomeres activates ATM (Karlseder et al. 1999), consistent with a mutually exclusive binding of shelterin and MRN to telomeric DNA (Wu et al. 2007).

Literature References
PubMed ID Title Journal Year
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Paull, TT, Lee, JH

Science 2005
10037601 p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

Karlseder, J, Broccoli, D, Hardy, S, Dai, Y, de Lange, T

Science 1999
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

Xiao, S, Wu, Y, Zhu, XD

Nat. Struct. Mol. Biol. 2007
Orthologous Events
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