Reactome | Activated MAPKs phosphorylate BRAF

Activated MAPKs phosphorylate BRAF

Stable Identifier

R-HSA-5675198

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        Negative feedback regulation of MAPK pathway (Homo sapiens)
        
        Activated MAPKs phosphorylate BRAF (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        Negative feedback regulation of MAPK pathway (Homo sapiens)
        
        Activated MAPKs phosphorylate BRAF (Homo sapiens)

General

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BRAF is subject to MAPK-dependent phosphorylation that limits its activity. Phosphorylation of S151 inhibits binding of BRAF to activated RAS, while phosphorylation of T401, S750 and S753 abrogates heterodimerization with RAF1 (Ritt et al, 2010; Rushworth et al, 2006; Brummer et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
14654779	Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf Brummer, T, Naegele, H, Reth, M, Misawa, Y	Oncogene	2003
16508002	Regulation and role of Raf-1/B-Raf heterodimerization Rushworth, LK, Hindley, AD, O'Neill, E, Kolch, W	Mol. Cell. Biol.	2006
19933846	Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling Ritt, DA, Monson, DM, Specht, SI, Morrison, DK	Mol. Cell. Biol.	2010