IL17RD binds p-2S MAP2Ks and MAPKs

Stable Identifier
Reaction [binding]
Homo sapiens
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IL17RD, also known as SEF (similar expression to FGF), was identified as a negative regulator of nuclear MAPK signaling (Tsang et al, 2002; Furthauer et al, 2002). IL17RD is a spatial regulator of MAPK signaling that binds activated MAP2K dimers at the Golgi membrane and prevents the dissociation and translocation of phosphorylated MAPK into the nucleus. In this way, IL17RD restricts activation of nuclear MAPK targets while not affecting activation of cytosolic ones (Torii et al, 2004; reviewed in Phillips, 2004; Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
11802164 Identification of Sef, a novel modulator of FGF signalling

Dawid, IB, Kudoh, T, Tsang, M, Friesel, R

Nat. Cell Biol. 2002
15260967 Sef: a MEK/ERK catcher on the Golgi

Philips, MR

Mol. Cell 2004
11802165 Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling

Ang, SL, Lin, W, F├╝rthauer, M, Thisse, B, Thisse, C

Nat. Cell Biol. 2002
15239952 Sef is a spatial regulator for Ras/MAP kinase signaling

Maekawa, M, Kusakabe, M, Yamamoto, T, Nishida, E, Torii, S

Dev Cell 2004
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
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