Reactome | IL17RD binds p-2S MAP2Ks and MAPKs

IL17RD binds p-2S MAP2Ks and MAPKs

Stable Identifier

R-HSA-5674366

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

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IL17RD, also known as SEF (similar expression to FGF), was identified as a negative regulator of nuclear MAPK signaling (Tsang et al, 2002; Furthauer et al, 2002). IL17RD is a spatial regulator of MAPK signaling that binds activated MAP2K dimers at the Golgi membrane and prevents the dissociation and translocation of phosphorylated MAPK into the nucleus. In this way, IL17RD restricts activation of nuclear MAPK targets while not affecting activation of cytosolic ones (Torii et al, 2004; reviewed in Phillips, 2004; Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
15260967	Sef: a MEK/ERK catcher on the Golgi Philips, MR	Mol. Cell	2004
11802164	Identification of Sef, a novel modulator of FGF signalling Tsang, M, Friesel, R, Kudoh, T, Dawid, IB	Nat. Cell Biol.	2002
11802165	Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling Fürthauer, M, Lin, W, Ang, SL, Thisse, B, Thisse, C	Nat. Cell Biol.	2002
15239952	Sef is a spatial regulator for Ras/MAP kinase signaling Torii, S, Kusakabe, M, Yamamoto, T, Maekawa, M, Nishida, E	Dev Cell	2004
21779496	Raf family kinases: old dogs have learned new tricks Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W	Genes Cancer	2011