IL17RD, also known as SEF (similar expression to FGF), was identified as a negative regulator of nuclear MAPK signaling (Tsang et al, 2002; Furthauer et al, 2002). IL17RD is a spatial regulator of MAPK signaling that binds activated MAP2K dimers at the Golgi membrane and prevents the dissociation and translocation of phosphorylated MAPK into the nucleus. In this way, IL17RD restricts activation of nuclear MAPK targets while not affecting activation of cytosolic ones (Torii et al, 2004; reviewed in Phillips, 2004; Matallanas et al, 2011).
Philips, MR
Tsang, M, Friesel, R, Kudoh, T, Dawid, IB
Fürthauer, M, Lin, W, Ang, SL, Thisse, B, Thisse, C
Torii, S, Kusakabe, M, Yamamoto, T, Maekawa, M, Nishida, E
Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W
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