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Schema
>
BlackBoxEvent
>
Entries
MAP2Ks and MAPKs are phosphorylated at the endosome membrane
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authored
[InstanceEdit:5674037] Rothfels, Karen, 2015-02-10
category
omitted
compartment
[Compartment:74700] endosome membrane
created
[InstanceEdit:5674137] Rothfels, Karen, 2015-02-10
dbId
5674130
displayName
MAP2Ks and MAPKs are phosphorylated at the endosome membrane
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf
[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5653914] Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
[LiteratureReference:5674093] MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling
[LiteratureReference:5674097] MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
[LiteratureReference:5674100] Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
[LiteratureReference:5674127] p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
modified
[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name
MAP2Ks and MAPKs are phosphorylated at the endosome membrane
orthologousEvent
[BlackBoxEvent:R-BTA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Bos taurus
[BlackBoxEvent:R-DDI-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Dictyostelium discoideum
[BlackBoxEvent:R-CEL-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Caenorhabditis elegans
[BlackBoxEvent:R-DME-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Drosophila melanogaster
[BlackBoxEvent:R-DRE-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Danio rerio
[BlackBoxEvent:R-SSC-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Sus scrofa
[BlackBoxEvent:R-CFA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Canis familiaris
[BlackBoxEvent:R-RNO-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Rattus norvegicus
[BlackBoxEvent:R-MMU-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-5674131] WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane]
precedingEvent
[Reaction:R-HSA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Homo sapiens
releaseDate
2015-06-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5674130
summation
[Summation:5674084] Interaction of MAPK pathway components with LAMTOR2, 3 and M...
Referrals
(hasEvent)
[Pathway:R-HSA-5674135] MAP2K and MAPK activation
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