Reactome | MAP2Ks and MAPKs are phosphorylated at the endosome membrane

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MAP2Ks and MAPKs are phosphorylated at the endosome membrane Show undefined attributes

authored	[InstanceEdit:5674037] Rothfels, Karen, 2015-02-10
category	omitted
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:5674137] Rothfels, Karen, 2015-02-10
dbId	5674130
displayName	MAP2Ks and MAPKs are phosphorylated at the endosome membrane
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5653914] Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction [LiteratureReference:5674093] MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling [LiteratureReference:5674097] MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade [LiteratureReference:5674100] Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists [LiteratureReference:5674127] p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAP2Ks and MAPKs are phosphorylated at the endosome membrane
orthologousEvent	[BlackBoxEvent:R-DDI-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Dictyostelium discoideum [BlackBoxEvent:R-CEL-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Caenorhabditis elegans [BlackBoxEvent:R-DME-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Drosophila melanogaster [BlackBoxEvent:R-DRE-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Danio rerio [BlackBoxEvent:R-SSC-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Sus scrofa [BlackBoxEvent:R-BTA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Bos taurus [BlackBoxEvent:R-CFA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Canis familiaris [BlackBoxEvent:R-RNO-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5674131] WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-HSA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5674130
summation	[Summation:5674084] Interaction of MAPK pathway components with LAMTOR2, 3 and M...

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[Pathway:R-HSA-5674135] MAP2K and MAPK activation