MAP2Ks and MAPKs are phosphorylated at the endosome membrane

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Interaction of MAPK pathway components with LAMTOR2, 3 and MORG1 facilitates pathway activation in response to varied stimuli, resulting in the phosphorylation of MAP2K and MAPK proteins at conserved sites in their activation loops (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
12479806 Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

Teis, D, Huber, LA, Wunderlich, W

Dev. Cell 2002
15547943 MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling

Sharma, C, Eblen, ST, Weber, MJ, Catling, AD, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ

J. Cell. Biochem. 2005
17178906 p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

Teis, D, Kurzbauer, R, Villunger, A, de Araujo, ME, Geley, S, Erlacher, M, Offterdinger, M, Huber, LA, Taub, N, Hess, MW, Klein, C, Hilber, D, Bohn, G

J. Cell Biol. 2006
9733512 MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Eblen, ST, Weber, MJ, Collier, LS, Catling, AD, Schaeffer, HJ, Krauss, A

Science 1998
15118098 Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

Weber, MJ, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ, Bissonette, EA, Smolkin, ME

Proc. Natl. Acad. Sci. U.S.A. 2004
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
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