Reactome | MAP2Ks and MAPKs are phosphorylated at the endosome membrane

MAP2Ks and MAPKs are phosphorylated at the endosome membrane

Stable Identifier

R-HSA-5674130

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

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MAP2Ks and MAPKs are phosphorylated at the endosome membrane

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Interaction of MAPK pathway components with LAMTOR2, 3 and MORG1 facilitates pathway activation in response to varied stimuli, resulting in the phosphorylation of MAP2K and MAPK proteins at conserved sites in their activation loops (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
12479806	Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction Teis, D, Huber, LA, Wunderlich, W	Dev. Cell	2002
15547943	MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling Sharma, C, Eblen, ST, Weber, MJ, Catling, AD, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ	J. Cell. Biochem.	2005
17178906	p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis Teis, D, Kurzbauer, R, Villunger, A, de Araujo, ME, Geley, S, Erlacher, M, Offterdinger, M, Huber, LA, Taub, N, Hess, MW, Klein, C, Hilber, D, Bohn, G	J. Cell Biol.	2006
9733512	MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade Eblen, ST, Weber, MJ, Collier, LS, Catling, AD, Schaeffer, HJ, Krauss, A	Science	1998
15118098	Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists Weber, MJ, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ, Bissonette, EA, Smolkin, ME	Proc. Natl. Acad. Sci. U.S.A.	2004
21779496	Raf family kinases: old dogs have learned new tricks Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A	Genes Cancer	2011