Reactome | MAP2Ks and MAPKs are phosphorylated at the endosome membrane

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MAP2Ks and MAPKs are phosphorylated at the endosome membrane Show undefined attributes

category	omitted
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10404750
displayName	MAP2Ks and MAPKs are phosphorylated at the endosome membrane
eventOf	[Pathway:R-BTA-5674135] MAP2K and MAPK activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MAP2Ks and MAPKs are phosphorylated at the endosome membrane
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-5674131] WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-BTA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-5674130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5674135] MAP2K and MAPK activation
(inferredTo)	[BlackBoxEvent:R-HSA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane

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