Reactome | Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP

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Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5668645] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:263698] phagolysosome [Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol [Compartment:21994] phagocytic vesicle
created	[InstanceEdit:5668636] Orlic-Milacic, Marija, 2015-01-26
crossReference	[DatabaseIdentifier:12667920] RHEA:63180
dbId	5668629
displayName	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:9626901] Shamovsky, Veronica, 2018-10-29
eventOf	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-1236709] O2 [phagolysosome]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5668623] Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 [LiteratureReference:5668616] Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways [LiteratureReference:5668630] PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils [LiteratureReference:5668610] Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism [LiteratureReference:5668615] p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process [LiteratureReference:1996219] The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases [LiteratureReference:1996210] Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes [LiteratureReference:5668665] Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense [LiteratureReference:5668679] Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
orthologousEvent	[Reaction:R-GGA-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Gallus gallus [Reaction:R-XTR-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Xenopus tropicalis [Reaction:R-DRE-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Danio rerio [Reaction:R-SSC-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Sus scrofa [Reaction:R-BTA-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Bos taurus [Reaction:R-CFA-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Canis familiaris [Reaction:R-RNO-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Rattus norvegicus [Reaction:R-MMU-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-2000345] O2.- [phagolysosome]
precedingEvent	[Reaction:R-HSA-5668605] RAC2:GTP binds NOX2 complex - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-6798187] Positive regulation by 'PI3P [cytosol]' [PositiveRegulation:9628201] Positive regulation by 'NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]'
regulationReference	[RegulationReference:9642939] Positive regulation by 'NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]' Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5668629
summation	[Summation:5668666] RAC2:GTP-bound NOX2 complex, consisting of CYBB (NOX2), CYBA...
updateTrackers	[UpdateTracker:9778710] Update Tracker - [Reaction:5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - v67:[add_removeInput, add_removeOutput, add_removeRegulator] [UpdateTracker:9783834] Update Tracker - [Reaction:5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - v55:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9778710] Update Tracker - [Reaction:5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - v67:[add_removeInput, add_removeOutput, add_removeRegulator] [UpdateTracker:9783834] Update Tracker - [Reaction:5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - v55:[addRegulator]
(hasEvent)	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases

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