Reactome | Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP

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Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP Show undefined attributes

catalystActivity	[CatalystActivity:10292551] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:263698] phagolysosome [Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol [Compartment:21994] phagocytic vesicle
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292563
displayName	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
eventOf	[Pathway:R-CFA-5668599] RHO GTPases Activate NADPH Oxidases - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-1236709] O2 [phagolysosome]
isInDisease	false
isInferred	true
maxDepth	1
name	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-2000345] O2.- [phagolysosome]
precedingEvent	[Reaction:R-CFA-5668605] RAC2:GTP binds NOX2 complex - Canis familiaris
regulatedBy	[PositiveRegulation:R-HSA-6798187] Positive regulation by 'PI3P [cytosol]' [PositiveRegulation:10292564] Positive regulation by 'NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5668629
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5668599] RHO GTPases Activate NADPH Oxidases
(inferredTo)	[Reaction:R-HSA-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP

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