Reactome | cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

Schema > BlackBoxEvent > Entries

cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK Show undefined attributes

authored	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
catalystActivity	[CatalystActivity:5668529] ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
catalystActivityReference	[CatalystActivityReference:9643336] ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5668515] Garapati, Phani Vijay, 2015-01-26
dbId	5668534
displayName	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
edited	[InstanceEdit:5668484] Garapati, Phani Vijay, 2015-01-26
eventOf	[Pathway:R-HSA-5668541] TNFR2 non-canonical NF-kB pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5668520] 26Sproteasome degrades K48polyUb-NIK - Homo sapiens
input	[Complex:R-HSA-5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Polymer:R-HSA-912740] K48polyUb [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5668419] Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK [LiteratureReference:5668533] Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
orthologousEvent	[BlackBoxEvent:R-GGA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Gallus gallus [BlackBoxEvent:R-XTR-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Xenopus tropicalis [BlackBoxEvent:R-DRE-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Danio rerio [BlackBoxEvent:R-SSC-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Sus scrofa [BlackBoxEvent:R-BTA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Bos taurus [BlackBoxEvent:R-CFA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Canis familiaris [BlackBoxEvent:R-RNO-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Rattus norvegicus [BlackBoxEvent:R-MMU-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5668525] K48polyUb-NIK [cytosol] [Complex:R-HSA-5668489] TRAF2:cIAP1,2 [cytosol] [EntityWithAccessionedSequence:R-HSA-914241] TRAF3 [cytosol]
precedingEvent	[Reaction:R-HSA-5668543] TRAF3:NIK binds TRAF2:cIAP1/2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5676484] Negative regulation by 'TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]'
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5668534
summation	[Summation:5668528] TNF receptor-associated factor 2 (TRAF2) and cellular inhibi...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-5668520] 26Sproteasome degrades K48polyUb-NIK
(hasEvent)	[Pathway:R-HSA-5668541] TNFR2 non-canonical NF-kB pathway