Reactome | cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

Stable Identifier

R-HSA-5668534

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

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TNF receptor-associated factor 2 (TRAF2) and cellular inhibitors of apoptosis 1 and 2 (cIAP1,2) are both RING-containing ubiquitin protein ligase (E3), and the interplay between these two protein families and other molecules in the receptor complex is critical in the propagation of downstream signals (Rothe et al. 1995, Yang et al., 2000). cIAP1,2 initiates proteasomal degradation of NIK by mediating its K48-linked ubiquitination (K48-(Ub)n).

Literature References

PubMed ID	Title	Journal	Year
18997794	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK Mahoney, DJ, Wang, Y, Shiba, T, Mak, TW, Yeh, WC, Cheng, G, Dempsey, PW, He, J, Cheung, HH, Korneluk, RG, Yang, X, Zarnegar, BJ	Nat. Immunol.	2008
10797013	Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli Yang, Y, Weissman, AM, Ashwell, JD, Jensen, JP, Fang, S	Science	2000