cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

Stable Identifier
Reaction [omitted]
Homo sapiens
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TNF receptor-associated factor 2 (TRAF2) and cellular inhibitors of apoptosis 1 and 2 (cIAP1,2) are both RING-containing ubiquitin protein ligase (E3), and the interplay between these two protein families and other molecules in the receptor complex is critical in the propagation of downstream signals (Rothe et al. 1995, Yang et al., 2000). cIAP1,2 initiates proteasomal degradation of NIK by mediating its K48-linked ubiquitination (K48-(Ub)n).

Literature References
PubMed ID Title Journal Year
18997794 Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Mahoney, DJ, Wang, Y, Shiba, T, Mak, TW, Yeh, WC, Cheng, G, Dempsey, PW, He, J, Cheung, HH, Korneluk, RG, Yang, X, Zarnegar, BJ

Nat. Immunol. 2008
10797013 Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

Yang, Y, Weissman, AM, Ashwell, JD, Jensen, JP, Fang, S

Science 2000
Catalyst Activity

ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol]

This event is regulated