TNF receptor-associated factor 2 (TRAF2) and cellular inhibitors of apoptosis 1 and 2 (cIAP1,2) are both RING-containing ubiquitin protein ligase (E3), and the interplay between these two protein families and other molecules in the receptor complex is critical in the propagation of downstream signals (Rothe et al. 1995, Yang et al., 2000). cIAP1,2 initiates proteasomal degradation of NIK by mediating its K48-linked ubiquitination (K48-(Ub)n).
Yang, Y, Fang, S, Jensen, JP, Weissman, AM, Ashwell, JD
Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G
ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
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