Reactome | cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

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cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK Show undefined attributes

catalystActivity	[CatalystActivity:10793241] ubiquitin-protein transferase activity of cIAP1,2:TRAF2:TRAF3:NIK [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10793243
displayName	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
eventOf	[Pathway:R-GGA-5668541] TNFR2 non-canonical NF-kB pathway - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-5668520] 26Sproteasome degrades K48polyUb-NIK - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Homo sapiens
input	[Complex:R-GGA-5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Polymer:R-GGA-912740] K48polyUb [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
output	[EntityWithAccessionedSequence:R-GGA-5668525] K48polyUb-NIK [cytosol] [Complex:R-GGA-5668489] TRAF2:cIAP1,2 [cytosol] [EntityWithAccessionedSequence:R-GGA-914241] TRAF3 [cytosol]
precedingEvent	[Reaction:R-GGA-5668543] TRAF3:NIK binds TRAF2:cIAP1/2 - Gallus gallus
regulatedBy	[NegativeRegulation:10793244] Negative regulation by 'TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-5668534
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[BlackBoxEvent:R-GGA-5668520] 26Sproteasome degrades K48polyUb-NIK
(inferredTo)	[BlackBoxEvent:R-HSA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

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