Reactome | Melanin biosynthesis

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Melanin biosynthesis Show undefined attributes

authored	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
created	[InstanceEdit:5662656] Jupe, Steve, 2015-01-13
dbId	5662702
displayName	Melanin biosynthesis
doi	10.3180/R-HSA-5662702.5
edited	[InstanceEdit:5673776] Jupe, Steve, 2015-02-10
eventOf	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:12141] melanin biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5662662] Tyrosinase oxidises tyrosine to dopaquinone - Homo sapiens [Reaction:R-HSA-5662669] Dopaquinone transforms to Leucodopachrome (Cyclodopa) - Homo sapiens [Reaction:R-HSA-5672019] Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa - Homo sapiens [Reaction:R-HSA-5662692] Dopa is oxidized to dopaquinone by TYR - Homo sapiens [Reaction:R-HSA-5662908] Dopaquinone, cysteine form CD isomers - Homo sapiens [Reaction:R-HSA-5662904] CD isomers transform to BTCA, BZ, ODHBT - Homo sapiens [BlackBoxEvent:R-HSA-5662891] pheomelanin formation - Homo sapiens [Reaction:R-HSA-5662660] Dopachrome is transformed to DHICA by DCT - Homo sapiens [Reaction:R-HSA-8878581] TYRP1 oxidises DHICA to IQCA - Homo sapiens [Reaction:R-HSA-5662706] Dopachrome transforms to DHI - Homo sapiens [BlackBoxEvent:R-HSA-5663050] DHI and DHICA polymerize forming eumelanin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-10-05
literatureReference	[LiteratureReference:5662862] Chemistry of mixed melanogenesis--pivotal roles of dopaquinone [LiteratureReference:5672022] Melanins and melanogenesis: methods, standards, protocols
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Melanin biosynthesis
orthologousEvent	[Pathway:R-GGA-5662702] Melanin biosynthesis - Gallus gallus [Pathway:R-DDI-5662702] Melanin biosynthesis - Dictyostelium discoideum [Pathway:R-CEL-5662702] Melanin biosynthesis - Caenorhabditis elegans [Pathway:R-XTR-5662702] Melanin biosynthesis - Xenopus tropicalis [Pathway:R-DRE-5662702] Melanin biosynthesis - Danio rerio [Pathway:R-SSC-5662702] Melanin biosynthesis - Sus scrofa [Pathway:R-BTA-5662702] Melanin biosynthesis - Bos taurus [Pathway:R-CFA-5662702] Melanin biosynthesis - Canis familiaris [Pathway:R-RNO-5662702] Melanin biosynthesis - Rattus norvegicus [Pathway:R-MMU-5662702] Melanin biosynthesis - Mus musculus
releaseDate	2015-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5674576] Ito, Shosuke, 2015-02-13 [InstanceEdit:5674585] d'Ischia, Marco, 2015-02-13 [InstanceEdit:9943296] Hill, David P, 2025-03-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5662702
summation	[Summation:5662673] Melanin biosynthesis takes place in specialized cells called...
updateTrackers	[UpdateTracker:9782779] Update Tracker - [Pathway:5662702] Melanin biosynthesis - v58:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782779] Update Tracker - [Pathway:5662702] Melanin biosynthesis - v58:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-71291] Metabolism of amino acids and derivatives

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