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Schema
>
FailedReaction
>
Entries
Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)
Show undefined attributes
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authored
[InstanceEdit:5661189] Jassal, Bijay, 2015-01-09
catalystActivity
[CatalystActivity:9631783] bile acid transmembrane transporter activity of SLCO1B1 mutants [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:5661189] Jassal, Bijay, 2015-01-09
crossReference
[DatabaseIdentifier:12020864] Mondo:0002408
dbId
5661184
deleted
[Deleted:9661803] Deletion of instance: 5661195
disease
[Disease:5605024] bilirubin metabolic disorder
displayName
Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)
edited
[InstanceEdit:5661189] Jassal, Bijay, 2015-01-09
entityFunctionalStatus
[EntityFunctionalStatus:5661206] loss_of_function of SLCO1B1 mutants [plasma membrane]
eventOf
[Pathway:R-HSA-5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) - Homo sapiens
input
[SimpleEntity:R-ALL-9661418] BIL [extracellular region]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5661196] Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)
normalReaction
[Reaction:R-HSA-9661397] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
revised
[InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5661184
summation
[Summation:5661187] The solute carrier organic anion transporter family member 1...
updateTrackers
[UpdateTracker:9778296] Update Tracker - [FailedReaction:5661184] Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - v68:[addCatalystActivity]
[UpdateTracker:9777421] Update Tracker - [FailedReaction:5661184] Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - v71:[add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9778296] Update Tracker - [FailedReaction:5661184] Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - v68:[addCatalystActivity]
[UpdateTracker:9777421] Update Tracker - [FailedReaction:5661184] Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - v71:[add_removeInput, modifyText]
(replacementInstances)
[Deleted:9661803] Deletion of instance: 5661195
(hasEvent)
[Pathway:R-HSA-5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
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