Reactome | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)

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Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) Show undefined attributes

authored	[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
created	[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
crossReference	[DatabaseIdentifier:12020864] Mondo:0002408
dbId	5619110
deleted	[Deleted:9661804] Deletion of instance: 5661182
disease	[Disease:5605024] bilirubin metabolic disorder
displayName	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
edited	[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
eventOf	[Pathway:R-HSA-5619102] SLC transporter disorders - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5661184] Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-12-10
literatureReference	[LiteratureReference:5661196] Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver [LiteratureReference:5605017] New insights in bilirubin metabolism and their clinical implications [LiteratureReference:5661193] The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
normalPathway	[Pathway:R-HSA-189445] Metabolism of porphyrins
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
revised	[InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5619110
summation	[Summation:5661203] The solute carrier organic anion transporter family member 1...
updateTrackers	[UpdateTracker:9777420] Update Tracker - [Pathway:5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) - v71:[modifyText, updateContainedRLE] [UpdateTracker:9778188] Update Tracker - [Pathway:5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) - v68:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9777420] Update Tracker - [Pathway:5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) - v71:[modifyText, updateContainedRLE] [UpdateTracker:9778188] Update Tracker - [Pathway:5619110] Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) - v68:[updateContainedRLE]
(replacementInstances)	[Deleted:9661804] Deletion of instance: 5661182
(hasEvent)	[Pathway:R-HSA-5619102] SLC transporter disorders

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