RAS GAPs stimulate RAS GTPase activity

Stable Identifier
R-HSA-5658231
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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RAS GAPs stimulate RAS GTPase activity
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The intrinsic GTPase activity of RAS proteins is stimulated by the GAP proteins, of which there are at least 10 in the human genome (reviewed in King et al, 2013).
Literature References
PubMed ID Title Journal Year
23443682 Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

Lapinski, PE, Lubeck, BA, King, PD

Sci Signal 2013
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Output
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Catalyst Activity

GTPase activity of p21 RAS:GTP:RAS GAPs [plasma membrane]

Physical Entity
p21 RAS:GTP:RAS GAPs [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
RAS GAPs stimulate RAS GTPase activity (Canis familiaris)
RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)
RAS GAPs stimulate RAS GTPase activity (Gallus gallus)
RAS GAPs stimulate RAS GTPase activity (Mus musculus)
RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)
RAS GAPs stimulate RAS GTPase activity (Sus scrofa)
Authored
Rothfels, K  (2014-12-10)
Reviewed
Pires, IM  (2016-02-07)
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2014-12-18)
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