Reactome | Activated FGFR2 binds FRS3

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Activated FGFR2 binds FRS3 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654602] Rothfels, Karen, 2014-12-03
dbId	5654603
deleted	[Deleted:5655571] Deletion of instance: 1268221
displayName	Activated FGFR2 binds FRS3
eventOf	[Pathway:R-HSA-5654700] FRS-mediated FGFR2 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654605] Activated FGFR2 phosphorylates FRS3 - Homo sapiens
input	[DefinedSet:R-HSA-5654152] Activated FGFR2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-191482] FRS3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors [LiteratureReference:532259] Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins [LiteratureReference:1268082] FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts [LiteratureReference:1549554] Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR2 binds FRS3
orthologousEvent	[Reaction:R-CEL-5654603] Activated FGFR2 binds FRS3 - Caenorhabditis elegans [Reaction:R-DME-5654603] Activated FGFR2 binds FRS3 - Drosophila melanogaster [Reaction:R-GGA-5654603] Activated FGFR2 binds FRS3 - Gallus gallus [Reaction:R-XTR-5654603] Activated FGFR2 binds FRS3 - Xenopus tropicalis [Reaction:R-DRE-5654603] Activated FGFR2 binds FRS3 - Danio rerio [Reaction:R-BTA-5654603] Activated FGFR2 binds FRS3 - Bos taurus [Reaction:R-CFA-5654603] Activated FGFR2 binds FRS3 - Canis familiaris [Reaction:R-RNO-5654603] Activated FGFR2 binds FRS3 - Rattus norvegicus [Reaction:R-MMU-5654603] Activated FGFR2 binds FRS3 - Mus musculus
output	[Complex:R-HSA-5654277] Activated FGFR2:FRS3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-190408] Autocatalytic phosphorylation of FGFR2b - Homo sapiens [Reaction:R-HSA-190413] Autocatalytic phosphorylation of FGFR2c - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654603
summation	[Summation:1268222] FRS3 (also known as FRS2beta) is predominantly expressed in ...

Referrals

(replacementInstances)	[Deleted:5655571] Deletion of instance: 1268221
(hasEvent)	[Pathway:R-HSA-5654700] FRS-mediated FGFR2 signaling
(precedingEvent)	[Reaction:R-HSA-5654605] Activated FGFR2 phosphorylates FRS3