Reactome | Activated FGFR2 binds FRS3

Activated FGFR2 binds FRS3

Stable Identifier

R-HSA-5654603

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        FRS-mediated FGFR2 signaling (Homo sapiens)
        
        Activated FGFR2 binds FRS3 (Homo sapiens)

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FRS3 (also known as FRS2beta) is predominantly expressed in the developing and adult neuroepithelium. As is the case for FRS2 (also known as FRS2alpha), binding of FRS3 to FGFR may be constitutive and/or independent of receptor activation. Elements of the downstream signaling mediated by the two FRS family members appear to be at least partially conserved, as FRS3 is phosphorylated upon FGF stimulation, binds PPTN11/SHP2 and GRB2 and results in ERK activation. Moreover, expression of FRS3 in FRS2-/- MEFs restores ERK activation.

Literature References

PubMed ID	Title	Journal	Year
9660748	Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins Xu, H, Lee, KW, Goldfarb, M	J Biol Chem	1998
10629055	FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors Ong, SH, Guy, GR, Hadari, YR, Laks, S, Gotoh, N, Schlessinger, J, Lax, I	Mol Cell Biol	2000
19187780	Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles Minegishi, Y, Iwanari, H, Mochizuki, Y, Horii, T, Hoshino, T, Kodama, T, Hamakubo, T, Gotoh, N	FEBS Lett	2009
15094036	FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts Gotoh, N, Laks, S, Nakashima, M, Lax, I, Schlessinger, J	FEBS Lett	2004